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Abstract #3322

Impact of native T1 on pixel-wise myocardial blood flow quantification

Corina Kräuter1,2, Ursula Reiter1, Clemens Reiter1, Albrecht Schmidt3, Michael Fuchsjäger1, Rudolf Stollberger2, and Gert Reiter4

1Department of Radiology, Medical University of Graz, Graz, Austria, 2Institute of Medical Engineering, Graz University of Technology, Graz, Austria, 3Department of Internal Medicine, Medical University of Graz, Graz, Austria, 4Research and Development, Siemens Healthineers, Graz, Austria

Native myocardial T1 varies between subjects and between segments, yet its impact on pixel-wise quantification of myocardial blood flow (MBF) has not been studied. 15 patients with coronary heart disease underwent 3T cardiac magnetic resonance native myocardial T1 mapping and perfusion imaging at rest. Nonlinearity correction for MBF calculation was performed employing literature native T1 values and patient-specific global as well as local native T1, respectively. Since reference T1 revealed substantial individual MBF errors and application of patient-specific global T1 overestimated MBF in perfusion deficit regions compared to local T1, patient-specific local native T1 should be employed for MBF quantification.

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