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Abstract #3338

Subtle differences in left ventricular cardiotoxicity remodeling between risk groups of cancer survivors based on strain analysis from cine-DENSE MRI

Delphine Perie-Curnier1, Denis Corbin1, Frederik Epstein2, Daniel Auger2, Tarik Hafyane3, and Daniel Curnier4

1Mechanical Engineering, Polytechnique Montreal, Montreal, QC, Canada, 2Biomedical Engineering, University of Virginia, Charlottesville, VA, United States, 3Research Center, Montreal Heart Institute, Montreal, QC, Canada, 4Kinesiology, University of Montreal, Montreal, QC, Canada

The aim of this study was to evaluate a reliable clinical tool to assess subtle differences in left ventricular cardiotoxicity remodeling in acute lymphoblastic leukemia survivors. Cine-DENSE MRI provided accurate evaluation of heart’s functionality of young cancer survivors in the short-axis view. Significant strain differences between groups were mostly observed in basal septal and apical septal segments while most of the other segments did not show significant differences. The next step of this study will be to include a control group of healthy volunteers.

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