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Abstract #3389

Empirical Sequence Design for Combined T2-Preparation and Outer Volume Suppression Preparation Sequence

David Y Zeng1, Mario O Malavé1, Corey A Baron1,2, Adam B Kerr1, Phillip C Yang3, Bob S Hu1,4, and Dwight G Nishimura1

1Electrical Engineering, Stanford University, Stanford, CA, United States, 2Medical Biophysics, Robarts Research Institute, London, ON, Canada, 3Cardiovascular Medicine, Stanford University, Stanford, CA, United States, 4Cardiology, Palo Alto Medical Foundation, Palo Alto, CA, United States

A new combined T2-prepared, multidimensional OVS pulse sequence was designed by an empirically-driven method. We defined a T2-prepared OVS module as a tip-down pulse, refocusing sequence, and a selective tip-up pulse. Candidate pulses were proposed for each portion of the module and all possible modules were evaluated by a metric based on Bloch simulations. Multidimensional OVS was achieved by concatenation of modules. The proposed sequence had the lowest metric and was compared against an existing T2-prepared OVS sequence for in vivo (n=5) coronary imaging. The proposed sequence had superior vessel sharpness, SNR, OVS, and qualitative reader scores.

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