Abstract #3389

Empirical Sequence Design for Combined T2-Preparation and Outer Volume Suppression Preparation Sequence

David Y Zeng¹, Mario O Malavé¹, Corey A Baron^1,2, Adam B Kerr¹, Phillip C Yang³, Bob S Hu^1,4, and Dwight G Nishimura¹

¹Electrical Engineering, Stanford University, Stanford, CA, United States, ²Medical Biophysics, Robarts Research Institute, London, ON, Canada, ³Cardiovascular Medicine, Stanford University, Stanford, CA, United States, ⁴Cardiology, Palo Alto Medical Foundation, Palo Alto, CA, United States

A new combined T₂-prepared, multidimensional OVS pulse sequence was designed by an empirically-driven method. We defined a T2_-prepared OVS module as a tip-down pulse, refocusing sequence, and a selective tip-up pulse. Candidate pulses were proposed for each portion of the module and all possible modules were evaluated by a metric based on Bloch simulations. Multidimensional OVS was achieved by concatenation of modules. The proposed sequence had the lowest metric and was compared against an existing T₂-prepared OVS sequence for in vivo (n=5) coronary imaging. The proposed sequence had superior vessel sharpness, SNR, OVS, and qualitative reader scores.

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