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Abstract #3456

Regional distribution of Local 3D Pulse Wave Velocity with and without Aortic Arch Replacement in Pediatric Patients with Single Ventricle

Amol S. Pednekar1, Matthew Goette1, Prakash Masand1, and Cory Noel2

1Radiology, Texas Children's Hospital, Houston, TX, United States, 2Cardiology, Texas Children's Hospital, Houston, TX, United States

PC-CMR permits precise discrete 3D aortic pulse wave velocity (PWV) measurements as a surrogate for changes in vascular stiffness and ventricular-vascular interaction. In this preliminary study, global PWVs are 50% higher in 3 single ventricle (SV) patients with reconstructed arch (RA) than 3 patients with native arch (NA). Furthermore, the regional distribution of PWVs in SV-RA indicates rapid deceleration (50-70%) from proximal to distal aorta that is absent in SV-NA. The abnormal shape, large caliber change, and prosthetic material of reconstructed aortas may be additional explanatory variables. Regional distribution of local PWVs could potentially predict development of abnormal ventricular-vascular interaction.

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