Abstract #3457

High Spatiotemporal Resolution Dynamic Contrast Enhanced (DCE) For Assessing Vascular Inflammation: Initial Clinical Experience

Nan Wang^1,2, Anthony Christodoulou¹, Yibin Xie¹, Zixin Deng^1,2, Bill Zhou^1,3, Zhaoyang Fan^1,3, Wei Yu⁴, and Debiao Li^1,2

¹Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ²Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, ³Department of Medicine, University of California, Los Angeles, Los Angeles, CA, United States, ⁴Department of Radiology, Anzhen Hospital, Beijing, China

Dynamic contrast enhanced (DCE) MRI is a promising technique for quantitatively assessing the inflammation of atherosclerosis. However, current applications are facing demanding sampling challenges, and compromises have to be made among spatial resolution, coverage and temporal resolution. We recently proposed a 3D DCE protocol based on Low Rank Tensor (LRT) framework to achieve high spatiotemporal resolution, adequate anatomical coverage and dynamic T1 mapping. In this work, we demonstrated the in vivo feasibility on both healthy subjects and patients with known atherosclerosis.

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