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Abstract #3458

An inverse association between microvasculature and intraplaque hemorrhage in atherosclerotic carotid lesions: an MR imaging study

Geneviève Crombag1,2, Raf van Hoof1, Floris Schreuder3, Martine Truijman4, Sylvia Heeneman5, Paul Nederkoorn6, Werner Mess2,7, Robert van Oostenbrugge2,4, Jan-Willem Daemen8, Mat Daemen9, Joachim Wildberger1,2, and Eline Kooi1,2

1Radiology & Nuclear Medicine, Maastricht University Medical Center, Maastricht, Netherlands, 2Cardiovascular Research Institute Maastricht, Maastricht, Netherlands, 3Department of Neurology & Donders Institute for Brain Cognition & Behaviour, Radboud University Medical Centre, Nijmegen, Netherlands, 4Neurology, Maastricht University Medical Center, Maastricht, Netherlands, 5Pathology, Maastricht University Medical Center, MAastricht, Netherlands, 6Neurology, Amsterdam Medical Center, Amsterdam, Netherlands, 7Clinical Neurophysiology, Maastricht University Medical Center, Maastricht, Netherlands, 8Surgery, Maastricht University Medical Center, Maastricht, Netherlands, 9Pathology, Amsterdam Medical Center, Amsterdam, Netherlands

The presence of intraplaque haemorrhage (IPH) has been related to plaque rupture, plaque progression, and predicts cerebrovascular events. However, the mechanisms leading to IPH are not fully understood. The dominant view is that IPH is caused by leakage of erythrocytes from immature microvessels. 101 patients underwent MRI of the symptomatic carotid plaque for detection of IPH and dynamic contrast-enhanced MRI for assessment of plaque microvasculature. A decreased vessel wall Ktrans was found for IPH positive patients. No difference in adventitial Ktrans was found in patients with and without IPH. Not only leaky plaque microvessels, but additional factors may contribute to IPH development.

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