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Abstract #3464

Quantitatively monitoring therapeutic response in  patients with symptomatic intracranial atherosclerotic disease using 3D MR plaque imaging

Zhaoyang Fan1,2, Qi Yang1,3, Feng Shi1, Shlee Song1, Konrad Schlick1, Mercel Maya1, Nestor Gonzalez1, and Debiao Li1

1Cedars-Sinai Medical Center, Los Angeles, CA, United States, 2University of California, Los Angeles, CA, United States, 3Xuanwu Hospital, Beijing, China

Intracranial atherosclerotic disease (ICAD) is one of the most common causes of ischemic stroke worldwide. Despite intensive medical management, which is the current standard of care, the rate of recurrent stroke is 13% in the first year and as high as 35% in certain populations by 2 years. Initial and follow-up evaluations of these patients rely exclusively on assessments of clinical risk factors and, in some circumstances, the degree of luminal stenosis on imaging, which may overlook subtle non-luminal changes within ICAD lesions. In the present work, we sought to assess the feasibility of quantitatively monitoring regression or progression of intracranial atherosclerotic plaques using 3D VWI.

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