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Abstract #3465

Quantitative and Noninvasive MRI of the Endothelial Permeability and Function in Carotid Atherosclerosis

Alkystis Phinikaridou1, Justinas Silickas2, Begoña Lavin1, Marcelo Andia3, Alberto Smith2, Prakash Saha2, and René Botnar2

1Biomedical Engineering, King's College London, London, United Kingdom, 2King's College London, London, United Kingdom, 3Pontificia Universidad Católica de Chile, Santiago, Chile

Over the past two decades, the central role of the endothelium in the initiation, progression, and clinical sequelae of atherosclerosis has been recognized. Increased endothelial permeability and impaired function precedes and portends the development of atherosclerotic lesions and their clinical manifestations. We have previously shown that quantitative assessment of albumin leakage into the vessel wall, using a clinically approved albumin-binding contrast agent, and endothelial-dependent dysfunction associated with lesion progression and instability in animal models. Here, we translated this technique in man to test whether endothelial permeability and dysfunction associate with carotid atherosclerosis risk in patients undergoing endarterectomy.

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