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Abstract #3473

Does the amount of signal change depend on calcium concentration in lipid-rich core plaque?

Yuki Kanazawa1, Kotaro Baba2, Tosiaki Miyati3, Masafumi Harada1, Hiroaki Hayashi1, Ikuho Kosaka2, Mitsuharu Miyoshi4, Michael Carl5, and Yuki Matsumoto6

1Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan, 2School of Health Sciences, Tokushima University, Tokushima, Japan, 3Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan, 4Global MR Applications and Workflow, GE Healthcare Japan, Hino, Japan, 5GE Healthcare, San Diego, CA, United States, 6Graduate school of Health Science, Tokushima University, Tokushima, Japan

The purpose of this study was to quantitatively detect calcification in LRNC plaques using multi-component analysis with UTE imaging. A phantom experiment was performed using a four echo-UTE sequence. The phantom consists of six different concentrations of hydroxyapatite (as calcification) and mayonnaise (as a lipid). The bi-exponential analysis with UTE enabled a split into two components of short- and long T2*successfully. R2* derived from each dataset increased with increasing concentrations of hydroxyapatite. In conclusion, multi-component T2* analysis with UTE makes it possible to evaluate calcification in atherosclerotic plaques.

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