Abstract #3473

Does the amount of signal change depend on calcium concentration in lipid-rich core plaque?

Yuki Kanazawa¹, Kotaro Baba², Tosiaki Miyati³, Masafumi Harada¹, Hiroaki Hayashi¹, Ikuho Kosaka², Mitsuharu Miyoshi⁴, Michael Carl⁵, and Yuki Matsumoto⁶

¹Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan, ²School of Health Sciences, Tokushima University, Tokushima, Japan, ³Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan, ⁴Global MR Applications and Workflow, GE Healthcare Japan, Hino, Japan, ⁵GE Healthcare, San Diego, CA, United States, ⁶Graduate school of Health Science, Tokushima University, Tokushima, Japan

The purpose of this study was to quantitatively detect calcification in LRNC plaques using multi-component analysis with UTE imaging. A phantom experiment was performed using a four echo-UTE sequence. The phantom consists of six different concentrations of hydroxyapatite (as calcification) and mayonnaise (as a lipid). The bi-exponential analysis with UTE enabled a split into two components of short- and long T₂^*successfully. R₂^* derived from each dataset increased with increasing concentrations of hydroxyapatite. In conclusion, multi-component T₂^* analysis with UTE makes it possible to evaluate calcification in atherosclerotic plaques.

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