Abstract #3474

Dynamic MRI of Nitroxide Radical for TEMPOL kinetics and Redox State Assessment in Porcine Aortic Wall

Maxim Terekhov¹, Mihaela Pali¹, Christian Wittke¹, David Lohr¹, Anja Schroeder², Sueleyman Erguen³, Alma Zernecke-Madsen⁴, Heike Walles², and Laura Maria Schreiber¹

¹Chair of Cellular and Molecular Imaging, Comprehensive Heart Failure Center, University Hospital Wuerzburg, Wuerzburg, Germany, ²Translational Center Regenerative Therapies, Fraunhofer Institute for Silicate Research, Wuerzburg, Wuerzburg, Germany, ³Institute of Anatomy and Cell Biology, University Wuerzburg, Wuerzburg, Germany, ⁴Institute for Experimental Biomedicine II, University Hospital Wuerzburg, Wuerzburg, Germany

Reactive oxygen species (ROS) plays a key role in vascular disease. The physiological mechanisms regulating vascular local oxidative stress (LOS) are not completely understood. Nitroxide radicals like TEMPOL have been used in basic science NMR studies of ROS and LOS. Therefore, we developed a technique for dynamic imaging of nitroxide radicals to assess their kinetics and redox state of tissue.

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