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Abstract #3474

Dynamic MRI of Nitroxide Radical for TEMPOL kinetics and Redox State Assessment in Porcine Aortic Wall

Maxim Terekhov1, Mihaela Pali1, Christian Wittke1, David Lohr1, Anja Schroeder2, Sueleyman Erguen3, Alma Zernecke-Madsen4, Heike Walles2, and Laura Maria Schreiber1

1Chair of Cellular and Molecular Imaging, Comprehensive Heart Failure Center, University Hospital Wuerzburg, Wuerzburg, Germany, 2Translational Center Regenerative Therapies, Fraunhofer Institute for Silicate Research, Wuerzburg, Wuerzburg, Germany, 3Institute of Anatomy and Cell Biology, University Wuerzburg, Wuerzburg, Germany, 4Institute for Experimental Biomedicine II, University Hospital Wuerzburg, Wuerzburg, Germany

Reactive oxygen species (ROS) plays a key role in vascular disease. The physiological mechanisms regulating vascular local oxidative stress (LOS) are not completely understood. Nitroxide radicals like TEMPOL have been used in basic science NMR studies of ROS and LOS. Therefore, we developed a technique for dynamic imaging of nitroxide radicals to assess their kinetics and redox state of tissue.

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