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Abstract #3478

DCE-MRI of Intracranial Artery Athoersclerosis: Quantitative Change After 6-month Statin Therapy.

Huijun Chen1, Jiaqi Dou1, Le He1, Chunyao Wang1, Haikun Qi1, Qiang Zhang1, and Xihai Zhao1

1Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua university, Beijing, China

Dynamic contrast-enhanced MRI (DCE-MRI) has been proven to be able to quantify the inflammation and neovasculature in the atherosclerotic plaque of carotid artery. However, few studies has focus on the DCE-MRI of intracranial artery atherosclerosis, which is another major cause of cerebral ischemic events. This study found that the Ktrans of intracranial artery calculated from DCE-MRI was significantly lower at follow-up comparing with baseline after 6-month statin therapy, suggesting DCE-MRI a good tool for therapeutic response evaluation for intracranial artery atherosclerosis

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