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Abstract #3557

The effect of ¹H-decoupling on hyperpolarized ¹³C signal decay – a study on choline chloride analogs and comparison to the effect of deuterium substitution of directly bonded protons

Sivaranjan Uppala1, Gamliel Ayelet1, Atara Nardi Schreiber1, Talia Harris1, Jacob Sosna1, J. Moshe Gomori1, and Rachel Katz-Brull1

1Hadassah-Hebrew University Medical Center, Jerusalem, Israel

The spin-lattice relaxation time (T1) of a DNP molecular probe is a key parameter in acquiring NMR signals in dissolution-DNP (d-DNP) experiments. Using molecular probes with long T1, NMR spin signals can survive for a duration sufficient for the study of metabolism (1-3 min). Deuteration of directly bonded 13C protonated positions has been useful in prolonging the visibility of hyperpolarized labeled 13C sites that are otherwise protonated. Here, we sought to investigate whether proton irradiation could affect the T1 of such 13C nuclei when such positions are in their naturally abundant form, i.e. directly bonded to protons.

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