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Abstract #3578

Intracellular Assembly of Olsalazine Nanoparticles for CEST MR Imaging and Cancer Therapy

Yue Yuan1, Xiaoliang Qi1, Jia Zhang1, Xiaolei Song1, Michael T. McMahon2, and Jeff W.M. Bulte1

1The Russell H. Morgan Department of Radiology and Radiological Science; Cellular Imaging Section, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2F.M. Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

Based on a biocompatible condensation reaction caused by tumor-related proprotein convertase furin, we developed a novel probe RRVR-Olsa for tumor-targeted CEST MR imaging and chemotherapy to accomplish theranostics. Our preliminary studies indicated that, RRVR-Olsa elicited an obvious increase in CEST signal and higher cytotoxicity on furin-overexpressing HCT116 cancer cells than on furin-deficient LoVo cells and on furin inhibitor-treated HCT116 cancer cells. In vivo CEST MRI with the use of RRVR-Olsa could readily distinguish the difference of furin expression in HCT116 tumor and LoVo tumor, which we attributed to the furin-directed intracellular self-assembly of RRVR-Olsa to olsalazine nanoparticles with enhanced accumulation.

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