Abstract #3577

First-pass Perfusion MRI of Myocardial Infarction Using a Novel Manganese Chelate Contrast Agent in a Rabbit Model

Lingyi Wen¹, Zhigang Yang², Hang Fu¹, Kun Zhang², Ran Sun¹, and Yingkun Guo¹

¹Department of Radiology, West China Second University Hospital, Sichuan University, Chengdu, China, ²Department of Radiology, West China Hospital, Sichuan University, Chengdu, China

First-pass perfusion MRI allows evaluation of myocardial perfusion in myocardial infarction (MI). While Gd³⁺-based contrast agents are incompatible with renal compromise, we designed and synthesized a novel manganese (Mn²⁺ ) based contrast agents. MI was induced in 4 rabbits, Mn²⁺ based and Gd³⁺-based first-pass perfusion MRI were performed on a 3.0T MRI scanner. All rabbits survived without significant differences in heart rate and left ventricular function. All the perfusion parameters of infarcted and normal myocardial segments correlated well between Gd-based and Mn-based perfusion imaging. Our novel Mn2+ contrast agents is safe and reliable to visualize myocardial perfusion in MI.

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