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Abstract #3576

Macrocyclic Xenon hosts: potential inhibitors and reporters for protein aggregation in Hyper-CEST MRI

Jan Oliver Jost1, Christopher Witte1, and Leif Schröder1

1Molecular Imaging, Leibniz Forschungsinstitut für Molekulare Pharmakologie, Berlin, Germany

Contrast agents for neurodegenerative diseases such as amyloidosis are challenging for MRI due to sensitivity limitations. Using hyperpolarized Xenon with special Xe hosts in combination with chemical excitation saturation transfer (CEST) has the potential to overcome this issue. It has been demonstrated that Cucurbit[7]uril (CB7) is inhibiting the fibrillation of Aβ40/ Aβ42 by interaction with its Phe residues. In parallel, we have demonstrated that CB7 can be used as a Xe-host. Here we present first results for a concept that uses CB7 as a drug and Xe biosensor simultaneously where binding of CB7 to Aβ40 can be detected by changing the Xe-HyperCEST signal.

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