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Abstract #3575

Improved Hyperpolarization of Solid and Mesoporous Nanoscale Silicon Particles Using TEMPO Radicals Allows In Vivo 29Si MRI

Nicholas Whiting1,2, Jingzhe Hu1,3, Shivanand Pudakalakatti1, Caitlin McCowan1,3, Hyeonglim Seo4, Youngbok Lee4, and Pratip Bhattacharya1

1The University of Texas MD Anderson Cancer Center, Houston, TX, United States, 2Rowan University, Glassboro, NJ, United States, 3Rice University, Houston, TX, United States, 4Hanyang University, Ansan, Republic of Korea

Hyperpolarized silicon microparticles have been previously demonstrated as in vivo MRI contrast agents; unfortunately, their large size and decreased mobility present limitations for targeted molecular imaging. While nanoscale silicon particles can also be hyperpolarized, their signal enhancement is typically limited by a low concentration of endogenous electrons. As such, no studies to date have demonstrated in vivo 29Si MRI of hyperpolarized nano-scale silicon. We demonstrate improved 29Si hyperpolarization with the addition of an exogenous radical species to both solid and mesoporous nanoparticle samples (30-300 nm diameter), which increases 29Si hyperpolarization and allows in vivo imaging of silicon nanoparticles.

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