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Abstract #3574

Feasibility of Imaging Lung Cancer Using Hyperpolarized MRI Technology

Mehrdad Pourfathi1, Luis Loza1, Stephen Kadlecek1, Ian Duncan1, Diane Lim2, Shampa Chatterjee3, Kai Ruppert1, Sarmad Siddiqui1, Harrilla Profka1, Yan Liu2, Jessica Kim2, Hooman Hamedani1, Yi Xin1, Faraz Amzajerdian1, Maurizio Cereda4, Ryan Baron1, Mary Spencer1, Tahmina Achekzai1, Jose Conejo-Garcia5, and Rahim R. Rizi1

1Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Sleep Medicine, University of Pennsylvania, Philadelphia, PA, United States, 3Physiology, University of Pennsylvania, Philadelphia, PA, United States, 4Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA, United States, 5Moffitt Cancer Center, Tampa, FL, United States

We demonstrate the feasibility of hyperpolarized MRI technology to image lung cancer in mice. We demonstrated the use of 13C MRSI to detect elevated pyruvate to lactate conversion in the tumor relative to the adjacent non-cancerous lung tissue. We also showed the feasibility of 129Xe imaging to detect non-aerated regions in the lung tissue co-localized with the tumor. The utility of these modalities combined may provide a multi-faceted tool to assess tumor's stage and its response to therapy in lung cancer.

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