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Abstract #3580

Imaging and discrimination of extracellular lactate in vivo using CEST and a paramagnetic shift reagent

Andre Martins1,2, Lei Zhang2, Veronica Clavijo-Jordan1, Alexander Funk1, Carlos Platas-Iglesias3, and A. Dean Sherry1,2

1Advanced Imaging Research Center, UTSW Medical Center, Dallas, TX, United States, 2UT Dallas, Richardson, TX, United States, 3Universidade da Coruña, Coruña, Spain

Glucose taken up by cancer cells is thought to be converted largely to lactate even in the presence of abundant oxygen although the amount of pyruvate diverted into the mitochondria is largely unknown. Hence, a method for imaging actual lactate production by tumors could be highly informative. We report in this work the design of several lanthanide-based shift reagents (SR) that form complexes with lactate and shift the lactate –OH CEST signal to a different frequency far away from water. Given that these SR’s are confined to extracellular space, the resulting lactate –OH CEST signal becomes a specific biomarker of lactate exported from cancer cells. This method offers great promise for imaging lactate production by tumors.

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