Meeting Banner
Abstract #3581

Low affinity zinc sensors for improved MRI detection of glucose-stimulated zinc(II) secretion from pancreatic beta-cells in vivo

Andre F Martins1,2, Veronica Clavijo-Jordan1, Sara Chirayil1, Shanrong Zhang1, Namini Paranawithana2, and A. Dean Sherry1,2

1Advanced Imaging Research Center, UTSW Medical Center, Dallas, TX, United States, 2UT Dallas, Richardson, TX, United States

We report here the design of several gadolinium-based MR contrast agents with different zinc affinities. The zinc sensors increased r1 in the presence of Zn2+ ions and more in the presence of serum albumin, only when zinc was present. The sensors with a lower affinity for Zn2+ enhanced better the MR contrast produced by zinc release in mouse pancreas due to reduced background signal. These lower affinity Zn2+ agents show great promise for detecting and monitoring the pharmacological effect of drugs in diabetes.

This abstract and the presentation materials are available to members only; a login is required.

Join Here