Heteronuclear-CEST imaging presents several unique properties when compared to 1H-CEST, which is based on water, including background-free signals, quantifyability and ability to monitor low concentrations of targets. Here we present the performance of the CEST approach in 19F-MRI framework for mapping multiple targets in a “multicolor” fashion. Specifically, the difference in binding kinetics between a 19F-agent and a molecular target (i.e., macrocyclic molecular host) and the different Δw values obtained in 19F-NMR lead to a clear 19F-CEST characteristics. The large 19F-CEST effect obtained and its Δw dependency allow the mapping of two molecular targets simultaneously using single 19F-probe.
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