Abstract #3584

Calcium-dependent molecular fMRI using a magnetic nanosensor

Benjamin B Bartelle¹, Satoshi Okada¹, Nan Li¹, Vincent Breton-Provencher², Mriganka Sur², and Alan P Jasanoff^1,2

¹Bioengineering, MIT, Cambridge, MA, United States, ²Brain & Cognitive Sciences, MIT, Cambridge, MA, United States

Superparamagnetic iron oxide nanoparticles are a modular platform technology for sensors with sub nM sensitivity and robust biomedical applications. In this work we engineer nanoparticle sensors that display Ca²⁺ dependent aggregation and demonstrate the first functional MRI study of Ca²⁺ dynamics as well as the first in vivo demonstration of a dynamic nanosensor.

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