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Abstract #3584

Calcium-dependent molecular fMRI using a magnetic nanosensor

Benjamin B Bartelle1, Satoshi Okada1, Nan Li1, Vincent Breton-Provencher2, Mriganka Sur2, and Alan P Jasanoff1,2

1Bioengineering, MIT, Cambridge, MA, United States, 2Brain & Cognitive Sciences, MIT, Cambridge, MA, United States

Superparamagnetic iron oxide nanoparticles are a modular platform technology for sensors with sub nM sensitivity and robust biomedical applications. In this work we engineer nanoparticle sensors that display Ca2+ dependent aggregation and demonstrate the first functional MRI study of Ca2+ dynamics as well as the first in vivo demonstration of a dynamic nanosensor.

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