Abstract #3591

Relaxation-compensated multi-pool CEST signal at 7T MRI of WHO IV gliomas is dependent on the anatomic localization

Constantin Dreher¹, Johanna Oberhollenzer¹, Johannes Windschuh², Jan-Eric Meißner², Felix Sahm³, Martin Bendszus⁴, Andreas Unterberg⁵, Wolfgang Wick⁶, Peter Bachert², Mark E. Ladd², Heinz-Peter Schlemmer¹, Moritz Zaiss⁷, Alexander Radbruch¹, and Daniel Paech¹

¹Radiology, DKFZ, Heidelberg, Germany, ²Medical Physics in Radiology, DKFZ, Heidelberg, Germany, ³Neuropathology, University Hospital Heidelberg, Heidelberg, Germany, ⁴Neuroradiology, University Hospital Heidelberg, Heidelberg, Germany, ⁵Neurosurgery, University Hospital Heidelberg, Heidelberg, Germany, ⁶Neurology, University Hospital Heidelberg, Heidelberg, Germany, ⁷Max-Planck-Institut, Tübingen, Germany

As patients with WHO IV° gliomas are still having a dismal prognosis, further tumor characterization is needed. With prognosis and histopathological parameters being dependent on tumor localization, and Chemical-Exchange-Saturation-Transfer(CEST) MRI at 7T being one of the latest advances in tumor imaging, we have prospectively evaluated CEST signals in 21 patients. Amide CEST and ADC parameters are significantly different with regard to brain hemispheres and correlating. CEST NOE(Nuclear Overhauser-Effect) is not different with regard to brain hemispheres, but in case of contact to the subventricular zone, which is accompanied by worse prognosis. NOE is possibly showing complementary information to Amide CEST.

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