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Abstract #3592

Detecting prostatic zinc (II) loss in a TRAMP prostate cancer model by glucose-stimulated zinc (II) secretion in vivo with MRI

Veronica Clavijo Jordan1, Alia Al-Ebraheem2, Su-Tang Lo1, Tina Geraki3, Andre F. Martins1,4, Sara Chirayil1, Neil M. Rofsky1, Michael Farquharson2, and A. Dean Sherry1,4

1University of Texas Southwestern Medical Center, Dallas, TX, United States, 2McMaster University, Hamilton, Canada, 3Diamond Light Source, Harwell, United Kingdom, 4University of Texas at Dallas, Richardson, TX, United States

We have previously found that glucose stimulates the secretion of zinc stores from epithelial cells in the prostate gland, and that this glucose-stimulated zinc secretion (GSZS) can be detected in vivo by a Gd-based zinc sensor with T1-weighted MRI. Here we elucidate the mechanisms of enhancement in the healthy prostate and loss of enhancement in the malignant prostate by GSZS MRI and Synchrotron-Radiation X-Ray Fluorescence (SR-XRF). GSZS MRI detects the unique loss of zinc content in the lateral lobe of the malignant prostate as observed by SR-XRF with a Gd-based high affinity Zn2+ sensor.

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