Meeting Banner
Abstract #3594

Imaging glucose-stimulated zinc secretion from the prostate and pancreas using a Mn(II)-based zinc sensor

Veronica Clavijo Jordan 1, Sara Chirayil1, Andre F Martins1,2, Namini Paranawithana2, James S Ratnakar1, and A. Dean Sherry 1,2

1University of Texas Southwestern Medical Center, Dallas, TX, United States, 2University of Texas at Dallas, Richardson, TX, United States

Imaging glucose-stimulated zinc secretion (GSZS) from secretory tissues has proven useful at assessing organ function and health; current probes to detect zinc secretion by MRI have so far been limited to gadolinium-based sensors. In this work we introduce a manganese-based zinc sensor and show that pancreatic and prostatic zinc detection is not compromised when using Mn instead of Gd for imaging GSZS in vivo. Biodistribution studies indicate that the Mn-based sensor is cleared intact after renal filtration but degraded during hepatobiliary clearance.

This abstract and the presentation materials are available to members only; a login is required.

Join Here