Imaging glucose-stimulated zinc secretion (GSZS) from secretory tissues has proven useful at assessing organ function and health; current probes to detect zinc secretion by MRI have so far been limited to gadolinium-based sensors. In this work we introduce a manganese-based zinc sensor and show that pancreatic and prostatic zinc detection is not compromised when using Mn instead of Gd for imaging GSZS in vivo. Biodistribution studies indicate that the Mn-based sensor is cleared intact after renal filtration but degraded during hepatobiliary clearance.
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