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Abstract #3605

Measuring the effect of soman, a seizure-inducing chemical warfare nerve agent, with simultaneous perfusion and brain oxygenation measurements

Kevin Lee1, Sara Bohnert2, Matthew Bouchard1, Ying Wu1, Cory Vair2, John Mikler2, and Jeff F Dunn1

1Radiology, University of Calgary, Calgary, AB, Canada, 2Casualty Management Section, Defence Research and Development Canada-Suffield Research Centre, Suffield, AB, Canada

Chemical warfare nerve agents induce neurological damage through seizures. It is widely accepted in the field of nerve agent research that excitotoxicity is the main contributor to the neuropathology. Growing evidence suggests the involvement of hypoxia in seizure-related neuropathology. However, it is difficult to detect hypoxia without directly measuring oxygenation. We applied a method we developed to simultaneously quantify tissue oxygenation and cerebral blood flow to detect hypoxia following soman-induced seizures.

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