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Abstract #3606

High Resolution 3D T1-weighted Black Blood MRI of Human Lenticulostriate Arteries as Biomarker for Small Vessel Diseases

Samantha J Ma1, Lirong Yan1, Lei Cao1, Giuseppe Barisano1, Marlene Casey1, John Ringman2, Meng Law1, Arthur Toga1, and Danny JJ Wang1

1Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, United States, 2Neurology, University of Southern California, Los Angeles, CA, United States

The early microvascular changes related to cerebral small vessel disease are still unclear. In this study, we applied a T1-weighted turbo spin echo sequence with variable flip angles for high resolution black-blood MRI to delineate the lenticulostriate arteries (LSA) at 3T. The vessel delineation was rated using a 4-point scale, and then correlated with clinical vascular risk factors as well as measures of executive function, cognitive flexibility and attention. LSA ratings were found to be reliable. Subjects with >4 visible LSA that were minimally tortuous exhibited positive trends with executive function, and male subjects tended to have poorer LSA delineation.

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