Abstract #3606

High Resolution 3D T1-weighted Black Blood MRI of Human Lenticulostriate Arteries as Biomarker for Small Vessel Diseases

Samantha J Ma¹, Lirong Yan¹, Lei Cao¹, Giuseppe Barisano¹, Marlene Casey¹, John Ringman², Meng Law¹, Arthur Toga¹, and Danny JJ Wang¹

¹Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, United States, ²Neurology, University of Southern California, Los Angeles, CA, United States

The early microvascular changes related to cerebral small vessel disease are still unclear. In this study, we applied a T1-weighted turbo spin echo sequence with variable flip angles for high resolution black-blood MRI to delineate the lenticulostriate arteries (LSA) at 3T. The vessel delineation was rated using a 4-point scale, and then correlated with clinical vascular risk factors as well as measures of executive function, cognitive flexibility and attention. LSA ratings were found to be reliable. Subjects with >4 visible LSA that were minimally tortuous exhibited positive trends with executive function, and male subjects tended to have poorer LSA delineation.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.