In Fabry Disease (FD) patients, compared to healthy controls, a significant increase in magnetic susceptibility has been observed in the substantia nigra and in the striatum, associated to a significant volume loss limited to the single substantia nigra. These findings probably reflect neurodegenerative phenomena due to pathological iron deposition in these particular extrapyramidal relay stations. This evidence supports the current hypothesis of a permeative cerebral involvement in FD that goes further the pure cerebrovascular association, thus shedding new light on this condition.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords