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Abstract #3610

Abnormal Gray Matter Structural networks in Idiopathic Normal Pressure Hydrocephalus

Lekang Yin1, Yanmei Yang2, Jianding Ye3, and Hong Yu3

1Radiology Deparment, Shanghai Chest Hospital, Shanghai, China, 2Radiology Department, Huashan Hospital of Fudan University, Shanghai, China, 3Radiology Department, Shanghai Chest Hospital, Shanghai, China

Idiopathic normal pressure hydrocephalus (iNPH) is a neurological disorder, the structural networks changes were never studied. We examined changes in gray matter structural network of patients with iNPH comparing with normal elderly people. Global network modularity was significantly larger in the iNPH network compared with the NC network (P<0.05). Eight nodes with significantly decreased betweenness were found in right frontal, temporal, insula lobe and right posterior cingulate region of iNPH network, while only one node was detected with significantly larger betweenness. Hubs of the iNPH network were mostly located in temporal areas and limbic lobe, while hubs of NC network were mainly located in frontal areas. We found some abnormalities in gray matter structural network that may relate to the occurrence of iNPH.

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