Abstract #3611

Structural and functional assessments of eye, brain and visual field in glaucoma using optical coherence tomography, magnetic resonance imaging and perimetry

Vivek Trivedi¹, Yue Chen², Carlos Parra¹, Ahmel Arshad³, Ji Won Bang¹, Mengfei Wu⁴, Ian Conner⁵, and Kevin Chan⁶

¹Department of Ophthalmology, New York University, New York, NY, United States, ²Department of Biomedical Engineering, Tsinghua University, Beijing, China, ³Touro College of Osteopathic Medicine, Middletown, NY, United States, ⁴Department of Population Health, New York University, New York, NY, United States, ⁵Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA, United States, ⁶Department of Ophthalmology, Department of Radiology, New York University, New York, NY, United States

We used 3-Tesla anatomical MRI, DTI, optical coherence tomography, and perimetry to assess structural and functional changes in the eye and brain in glaucoma patients across disease stages. Both optic nerve and optic chiasm volumes were found to decrease from early to advanced staged glaucoma, and were associated with inner retinal thinning and visual field functional loss. Fractional anisotropy, mean diffusivity, and radial diffusivity in optic radiation were significantly different from early to advanced staged patients, but not when comparing control to early disease states. These results suggest anatomical MRI and DTI may be useful in monitoring glaucomatous brain damages non-invasively across stages.

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