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Abstract #3614

Neurological symptoms and pathology in patients with newly-diagnosed, “classical” coeliac disease

Iain Croall1, Marios Hadjivassiliou1, Panagiotis Zis1, David S Sanders1, Pascale Aeschlimann2, Richard A Grünewald1, Paul Armitage1, Dan Connolly1, Daniel Aeschlimann2, and Nigel Hoggard1

1University of Sheffield, Sheffield, United Kingdom, 2Cardiff University, Cardiff, United Kingdom

Coeliac disease is known to cause neurological problems, although these are not well recognised by healthcare professionals. In this prospective study of 100 newly-diagnosed patients with classical coeliac disease, we show 67% to have neurological symptoms, and 46% to have abnormal NAA/Cr values by MR Spectroscopy investigation. Further, we demonstrate how participants with positivity to transglutaminase 6, an auto-antibody suggested to be involved in neuro-pathology of gluten-related disorders, are more likely to suffer these. Finally, we present a volumetric analysis showing subcortical atrophy in this sub-group. This study highlights the prevalence, and potential mechanisms, of neurological involvement in coeliac disease.

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