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Abstract #3616

Regional cortical folding morphometry in Friedreich ataxia using Laplace Beltrami based gyrification index

Rosita Shishegar1,2, Imis Dogan3,4, Martin B. Delatycki1,5,6,7, Gary F. Egan1,2, Elsdon Storey8, Louise A. Corben1,5,7, and Nellie Georgiou-Karistianis1

1School of Psychological Sciences and Monash Institute of Cognitive and Clinical Neurosciences, Monash University, Melbourne, Australia, 2Monash Biomedical Imaging, Monash University, Melbourne, Australia, 3Department of Neurology, RWTH Aachen University, Aachen, Germany, 4JARA - Translational Brain Medicine, Aachen and Juelich, Germany, 5Bruce Lefroy Centre for Genetic Health Research, Murdoch Childrens Research Institute, Melbourne, Australia, 6Clinical Genetics, Austin Health, Melbourne, Australia, 7Department of Paediatrics, The University of Melbourne, Melbourne, Australia, 8Department of Medicine, Monash University, Melbourne, Australia

Friedreich ataxia (FRDA) is an inherited neurodegenerative disorder mainly affecting the spinal cord and dentate nuclei of the cerebellum. Although there is growing evidence of cerebral atrophy and cortical thinning in FRDA, no research has investigated the pattern of cortical folding (gyrification) in the disorder. We have proposed a new MRI analysis technique, Laplace Beltrami based gyrification index (LB-GI), and validated its use in individuals with FRDA. Preliminary results reveal significantly increased regional gyrification in the motor cortex in individuals with FRDA, compared to healthy controls. Overall, our results demonstrate that LB-GI is a sensitive technique which requires further investigation as a potential neuroimaging marker of disease progression in FRDA.

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