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Abstract #3624

Whole-brain MRSI for Quantification of Metabolite Markers of Inflammation and Neuronal Integrity in HIV-1 Clade C Infection

Varan Govind1, Sameer Vyas2, Vivek Gupta2, Aman Sharma3, Sulaiman Sheriff1, Mahendra Kumar1, and Niranjan Khandelwal2

1University of Miami, Miami, FL, United States, 2Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education and Research, Chandigarh, India, 3Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India

HIV-1 enters the brain early in the course of infection and its replication continues despite use of combination anti-retrovirals (cART), causing chronic neuroinflammation, resulting in mild-to-moderate HIV-associated neurocognitive disorders in up to 50% of infected individuals. HIV-1 virus can be found throughout the brain of infected individuals, however, its maximum viral loads were found in the basal ganglia, frontal and medial temporal lobes, and hippocampus.1 We evaluated the use of a whole-brain proton MR spectroscopic imaging (MRSI) method at 3Tesla to better characterize the metabolite changes within the whole brain as a result of HIV infection.

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