Abstract #3624

Whole-brain MRSI for Quantification of Metabolite Markers of Inflammation and Neuronal Integrity in HIV-1 Clade C Infection

Varan Govind¹, Sameer Vyas², Vivek Gupta², Aman Sharma³, Sulaiman Sheriff¹, Mahendra Kumar¹, and Niranjan Khandelwal²

¹University of Miami, Miami, FL, United States, ²Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education and Research, Chandigarh, India, ³Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India

HIV-1 enters the brain early in the course of infection and its replication continues despite use of combination anti-retrovirals (cART), causing chronic neuroinflammation, resulting in mild-to-moderate HIV-associated neurocognitive disorders in up to 50% of infected individuals. HIV-1 virus can be found throughout the brain of infected individuals, however, its maximum viral loads were found in the basal ganglia, frontal and medial temporal lobes, and hippocampus.¹ We evaluated the use of a whole-brain proton MR spectroscopic imaging (MRSI) method at 3Tesla to better characterize the metabolite changes within the whole brain as a result of HIV infection.

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