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Abstract #3625

Overlap of R2* map based SN and SNpc defined by neuromelanin-sensitive MRI in Parkinson’s Disease: A promising diagnostic biomarker

Naying He1, Jason Langley2, Shengdi Chen3, Chunlei Liu4, Yong Zhang5, Fuhua Yan1, and Xiaoping Hu6

1Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 2Center for Advanced Neuroimaging, University of California, Riverside, Riverside, CA, United States, 3Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 4Department of Electrical Engineering and Computer Sciences, & Helen Wills Neuroscience Institute, University of California, Berkeley, San Francisco, CA, United States, 5MR Research, GE Healthcare, Shanghai, China, Shanghai, China, 6Department of Bioengineering University of California, Riverside, Riverside, CA, United States

There is an urgent need for developing diagnostic imaging biomarkers for Parkinson’s Disease (PD). In this work, we applied a standardized substantia nigra pars compacta (SNpc) mask based on neuromelanin-sensitive MR images from healthy subjects to investigate the diagnostic performance of the SNpc overlap percentage and R2* in the SNpc overlap in PD. R2* in the SNpc overlap volume was increased in PD patients as compared to controls. Furthermore, it was significantly positively correlated with the disease duration in PD. We found an excellent diagnostic accuracy for the SNpc overlap percentage (AUC, 0.927) in PD.

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