Abstract #3625

Overlap of R2* map based SN and SNpc defined by neuromelanin-sensitive MRI in Parkinson’s Disease: A promising diagnostic biomarker

Naying He¹, Jason Langley², Shengdi Chen³, Chunlei Liu⁴, Yong Zhang⁵, Fuhua Yan¹, and Xiaoping Hu⁶

¹Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ²Center for Advanced Neuroimaging, University of California, Riverside, Riverside, CA, United States, ³Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ⁴Department of Electrical Engineering and Computer Sciences, & Helen Wills Neuroscience Institute, University of California, Berkeley, San Francisco, CA, United States, ⁵MR Research, GE Healthcare, Shanghai, China, Shanghai, China, ⁶Department of Bioengineering University of California, Riverside, Riverside, CA, United States

There is an urgent need for developing diagnostic imaging biomarkers for Parkinson’s Disease (PD). In this work, we applied a standardized substantia nigra pars compacta (SNpc) mask based on neuromelanin-sensitive MR images from healthy subjects to investigate the diagnostic performance of the SNpc overlap percentage and R2* in the SNpc overlap in PD. R2* in the SNpc overlap volume was increased in PD patients as compared to controls. Furthermore, it was significantly positively correlated with the disease duration in PD. We found an excellent diagnostic accuracy for the SNpc overlap percentage (AUC, 0.927) in PD.

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