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Abstract #3626

Visualization of Substantia Nigra Pars Compacta: MPRAGE vs. DANTE T1-SPACE

Sonoko Oshima1, Yasutaka Fushimi1, Tomohisa Okada2, Takuya Hinoda1, Takayuki Yamamoto1, Hikaru Fukutomi1, Yusuke Yokota1, Akira Yamamoto1, Tsutomu Okada1, John Grinstead3, Sinyeob Ahn4, and Kaori Togashi1

1Department of Diagnostic Radiology and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 2Human Brain Research Center, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 3Siemens Healthineers, Portland, OR, United States, 4Siemens Healthineers, San Francisco, CA, United States

Neuromelanin-sensitive magnetic resonance techniques have been developed for depicting neuromelanin-rich structures such as substantia nigra pars compacta (SNpc). We compared visualization of SNpc between magnetization-prepared rapid gradient-echo imaging (MPRAGE) and delay alternating with nutation for tailored excitation-prepared T1-weighted variable flip angle turbo spin echo (DANTE T1-SPACE) in 21 healthy volunteers. DANTE T1-SPACE provided much better delineation of SNpc and showed higher signal intensity than MPRAGE. DANTE T1-SPACE can be used for evaluating SNpc.

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