Abstract #3626

Visualization of Substantia Nigra Pars Compacta: MPRAGE vs. DANTE T1-SPACE

Sonoko Oshima¹, Yasutaka Fushimi¹, Tomohisa Okada², Takuya Hinoda¹, Takayuki Yamamoto¹, Hikaru Fukutomi¹, Yusuke Yokota¹, Akira Yamamoto¹, Tsutomu Okada¹, John Grinstead³, Sinyeob Ahn⁴, and Kaori Togashi¹

¹Department of Diagnostic Radiology and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ²Human Brain Research Center, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ³Siemens Healthineers, Portland, OR, United States, ⁴Siemens Healthineers, San Francisco, CA, United States

Neuromelanin-sensitive magnetic resonance techniques have been developed for depicting neuromelanin-rich structures such as substantia nigra pars compacta (SNpc). We compared visualization of SNpc between magnetization-prepared rapid gradient-echo imaging (MPRAGE) and delay alternating with nutation for tailored excitation-prepared T1-weighted variable flip angle turbo spin echo (DANTE T1-SPACE) in 21 healthy volunteers. DANTE T1-SPACE provided much better delineation of SNpc and showed higher signal intensity than MPRAGE. DANTE T1-SPACE can be used for evaluating SNpc.

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