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Abstract #3633

White Matter Differences in Parkinson’s Disease: a 7Tesla Tract-Based Spatial Statistics Study

Remi Patriat1, Jacob Jacob Niederer1, Sommer Amundsen Huffmaster2, Matthew Petrucci2, Noam Harel1, Colum MacKinnon2, and Christophe Lenglet1

1Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, 2Neurology, University of Minnesota, Minneapolis, MN, United States

We used tract-based spatial statistics (TBBS) of 7Tesla fractional anisotropy (FA) measures to find differences between a cohort of early PD patients (N=30) and healthy controls (N=28). We examined the evolution of these differences by adding a PD cohort with longer disease duration (N=21). TBSS analysis revealed increased FA in the early PD group in the portions of the superior longitudinal fasciculus and the corticospinal tracts near M1, pre-motor and SMA. Subsequent analyses revealed increased FA in both PD groups compared to the control group. Radial diffusivity was significantly lower in the early and late PD groups compared to controls.

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