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Abstract #3634

Investigating differences in laterality and novel diffusion-derived metrics between freezing of gait (FOG) and non-FOG early Parkinson’s disease patients

Virendra R Mishra1, Zhengshi Yang1, Karthik Sreenivasan1, Xiaowei Zhuang1, Dietmar Cordes1, and Brent Bluett1

1Imaging, Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States

In this study, we utilized the diffusion MRI (dMRI) data of self-reported freezing of gait early Parkinson’s disease (PD-FOG) patients and PD-nonFOG patients from the Parkinson’s Progressive Markers Initiative (PPMI) database and investigated laterality along with the sensitivity of the conventional and advanced dMRI derived measures to classify the two groups. Our study revealed an asymmetric left laterality in early PD-FOG and a significant association of weighted fractional anisotropy with UPDRS scores in PD-FOG patients. Our study opens a window to understand disease severity using a potential new imaging biomarker for PD-FOG.

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