Abstract #3634

Investigating differences in laterality and novel diffusion-derived metrics between freezing of gait (FOG) and non-FOG early Parkinson’s disease patients

Virendra R Mishra¹, Zhengshi Yang¹, Karthik Sreenivasan¹, Xiaowei Zhuang¹, Dietmar Cordes¹, and Brent Bluett¹

¹Imaging, Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, United States

In this study, we utilized the diffusion MRI (dMRI) data of self-reported freezing of gait early Parkinson’s disease (PD-FOG) patients and PD-nonFOG patients from the Parkinson’s Progressive Markers Initiative (PPMI) database and investigated laterality along with the sensitivity of the conventional and advanced dMRI derived measures to classify the two groups. Our study revealed an asymmetric left laterality in early PD-FOG and a significant association of weighted fractional anisotropy with UPDRS scores in PD-FOG patients. Our study opens a window to understand disease severity using a potential new imaging biomarker for PD-FOG.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.