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Abstract #3635

Concurrent assessment of perfusion and functional connectivity in Parkinson’s disease

Maria Marcella Lagana1, Laura Pelizzari1,2, Niels Bergsland1,3, Alice Pirastru1, Giuseppe Baselli2, Mario Clerici1,4, Pietro Cecconi5, Raffaello Nemni1,4, and Francesca Baglio1

1Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy, 2Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milan, Italy, 3Buffalo Neuroimaging Analysis Center, Department of Neurology, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, United States, 4Università degli Studi di Milano, Milan, Italy, 5Radiology, Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy

We aimed to assess if resting state functional connectivity (FC) changes were related to hypoperfusion in a group of Parkinson’s disease (PD) patients. Independent component analysis was performed to identify common spatial patterns of FC and of arterial spin labeling perfusion separately, in the whole group of PD and healthy controls. Concurrent FC and perfusion group differences were assessed. The observed FC alteration in the visual network may be influenced by the significantly reduced cerebral blood flow in the lateral occipital cortex, and vice-versa. The cross-talk between functional and perfusion findings should be considered when interpreting the results.

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