Abstract #3637

White Matter Property of the Reward Circuits in Impulse Control Disorders in Parkinson’s Disease

Ru-Jen Lin¹, Weng-Ming Liu ², Yung-Chin Hsu³, Yu-Chen Wei³, Pin-Yu Chen ³, Joshua O Goh⁴, Wen-Yih Tseng³, and Ruey-Meei Wu⁵

¹Neurology Department, National Taiwan University Hospital Hsinchu branch, Hsinchu city, Taiwan, ²Neurology Department, Tzu Chi Hospital, Hualien City, Taiwan, ³Institute of Medical Device and Imaging, National Taiwan University, Taipei City, Taiwan, ⁴Graduate Institute of Brain and Mind Sciences, National Taiwan University, Taipei City, Taiwan, ⁵Neurology Department, National Taiwan University Hospital, Taipei City, Taiwan

Approximately 10-20% of Parkinson’s disease (PD) patients treated with dopamine agonist may develop impulse control disorder (ICD). We aimed to investigate microstructural characteristics of the white matter (WM) tracts in the reward circuits in PD-ICD by DSI images. ReMAP (Mean Apparent Propagator) was used for DSI reconstruction and TBAA (tract-based automatic analysis) for further tract analysis. Among the frontostriatal tracts (FS) and amygdala-related tracts, we found larger AD and/or RD in FS_motor cortex and amygdala-related tracts in ICD subjects, which may indicate a less healthy WM microstructure, and may further underlie the vulnerability to dopamine stimulation and result in hyper-gambling behavior.

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