Abstract #3639

Motor compensation in Parkinson’s disease (PD): a multimodal neuroimaging study

Nicolas Villain^1,2, Stéphane Lehéricy^2,3, Nadya Pyatigorskaya^2,3, Romain Valabrègue², Sara Fernandez-Vidal², Rahul Gaurav², Olivier Jaubert², Marie-Odile Habert⁴, Graziella Mangone^2,5, Jean-Christophe Corvol^1,2,5, Marie Vidailhet^1,2, and David Grabli^1,2

¹Neurology, Groupe Hospitalier Pitié Salpêtrière, Paris, France, ²Institut du Cerveau et de la Moelle Epinière, Paris, France, ³Neuroradiology, Groupe Hospitalier Pitié Salpêtrière, Paris, France, ⁴Nuclear Medicine, Groupe Hospitalier Pitié Salpêtrière, Paris, France, ⁵Centre d'Investigation de Recherche Clinique, Groupe Hospitalier Pitié Salpêtrière, Paris, France

Motor compensation mechanisms in PD rely on very distinct levels of evidence and have never been assessed altogether. They were tested among 68 early PD patients who underwent dopaminergic imaging and MRI (T1 neuromelanin, fMRI, DTI). We created an adjusted motor severity index (ratio between akinetic motor severity and neuromelanin substantia nigra alteration) and performed correlations between this index and the hypothesized compensation mechanisms. As a result, new dopaminergic synapses or more active dopaminergic synapses, reorganization of motor and cognitive subcortical loops and of the associative areas of the cerebellum are the main motor compensation mechanisms in early PD.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.