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Abstract #3641

Cerebellum and Sensory Motor Resting State Network Behaviors in tremor- and akinetic rigid -predominant patients with Parkinson’s disease

Jiaming Lu1, Prasanna Karunanayaka2, Eunyoung Lee3, Qing Yang2, Mechelle Lewis3, Paul Eslinger3, and Xuemei Huang3

1Radiology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, Nanjing, China, 2Radiology, Center for NMR Research, Penn State University College of Medicine, Hershey, PA, United States, 3Neurology, Penn State University College of Medicine, Hershey, PA, United States

The striatal dopamine depletion in Parkinson's disease (PD) explains clinical symptoms such as bradykinesia and rigidity, but not resting tremor thought to be associated with cerebellothalamic (CTC) circuit dysfunction. In this study we used resting state fMRI to investigate differences in the CTC network in akinetic-rigid (PDAR) and tremor predominant (PDT) PD patients with closely matched demographic and cognitive variables. The results support a type dependent functional disruption in the cerebellum and SMA rs-networks in PD patients with otherwise comparable disease severity, neurocognitive performance, and overall brain morphology.

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