This current study provides in vivo evidence that width and high signal were significantly decreased in SNc and LC of de novo PD patients using NM-MRI, compared with controls. We also observed that the neuromelanin changes in substantia nigra were across both motor phenotypic expressions and non-motor (with vs. without depressive symptoms) subtypes, while LC neuron reduction is more notable in PD with depressive symptoms. Our finding implies that the NM-MR imaging have potential applications to improve the clinical diagnosis and detect the heterogeneityof PD.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords