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Abstract #3642

Neuromelanin sensitive MRI features of substantia nigra and locus coeruleus in de novo Parkinson’s disease and its phenotypes

Lirong Jin1, Jian Wang2,3, Yuanfang Li1, Zhen Huang1, Yong Zhang4, Kai Liu2,3, and Mengsu Zeng2,3

1Neurology, Zhongshan Hospital, Fudan University, Shanghai, China, 2Radiology, Zhongshan Hospital, Fudan University, Shanghai, China, 3Shanghai Medical Imaging Institute, Shanghai, China, 4GE Healthcare, Shanghai, China

This current study provides in vivo evidence that width and high signal were significantly decreased in SNc and LC of de novo PD patients using NM-MRI, compared with controls. We also observed that the neuromelanin changes in substantia nigra were across both motor phenotypic expressions and non-motor (with vs. without depressive symptoms) subtypes, while LC neuron reduction is more notable in PD with depressive symptoms. Our finding implies that the NM-MR imaging have potential applications to improve the clinical diagnosis and detect the heterogeneityof PD.

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