Abstract #3642

Neuromelanin sensitive MRI features of substantia nigra and locus coeruleus in de novo Parkinson’s disease and its phenotypes

Lirong Jin¹, Jian Wang^2,3, Yuanfang Li¹, Zhen Huang¹, Yong Zhang⁴, Kai Liu^2,3, and Mengsu Zeng^2,3

¹Neurology, Zhongshan Hospital, Fudan University, Shanghai, China, ²Radiology, Zhongshan Hospital, Fudan University, Shanghai, China, ³Shanghai Medical Imaging Institute, Shanghai, China, ⁴GE Healthcare, Shanghai, China

This current study provides in vivo evidence that width and high signal were significantly decreased in SNc and LC of de novo PD patients using NM-MRI, compared with controls. We also observed that the neuromelanin changes in substantia nigra were across both motor phenotypic expressions and non-motor (with vs. without depressive symptoms) subtypes, while LC neuron reduction is more notable in PD with depressive symptoms. Our finding implies that the NM-MR imaging have potential applications to improve the clinical diagnosis and detect the heterogeneityof PD.

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