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Abstract #3647

Phase Sensitive Inversion Recovery (PSIR) spinal cord imaging as a potential biomarker for Motor Neuron Disease

Antje Bischof1, Nicholas T. Olney1,2, Howard J. Rosen1, Eduardo Caverzasi1, William A. Stern1, Catherine Lomen-Hoerth2, Bruce L. Miller1, Roland G. Henry1, and Nico Papinutto1

1Neurology, UCSF, San Francisco, CA, United States, 2Neurology, UCSF ALS center, UCSF, San Francisco, CA, United States

With this study we investigated whether spinal cord gray and white matter atrophy could be detected in vivo in patients with a diagnosis within the motor neuron disease spectrum using PSIR imaging. Gray and white matter were successfully delineated in ten patients. Gray and white matter atrophy was detected in the majority of patients even if the lower or upper motor neuron was clinically unaffected. Patients with predominantly bulbar symptoms did not show relevant spinal cord abnormalities. This suggests a possible role of PSIR imaging as a biomarker for the spatial and temporal distribution of pathological changes in motor neuron disease.

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