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Abstract #3648

Intracortical T1-weighted/T2-weighted ratio signal changes in Huntington’s Disease

Christopher D Rowley1, Sarah J Tabrizi2, Blair R Leavitt3, Raymund A.C. Roos4, Alexandra Durr5, and Nicholas A Bock1

1Neuroscience, McMaster University, Hamilton, ON, Canada, 2University College London, London, United Kingdom, 3University of British Columbia, Vancouver, BC, Canada, 4Leiden University Medical Centre, Leiden, Netherlands, 5Institut du Cerveau et de la Moelle Epinière, Paris, France

Huntington’s disease (HD) is a genetic neurodegenerative disorder that is characterized by motor and cognitive dysfunction. Previous imaging studies have shown cortical thickness is reduced in HD, and here we investigated potential changes in cortical tissue composition in Huntington’s based on previously acquired T1-weighted (T1W) and T2-weighted (T2W) images. We analyzed T1W/T2W ratios formed using images collected in 321 subjects from the TRACK-HD dataset representing various stages of HD and healthy controls. Intracortical T1W/T2W signal analysis revealed significant changes in the most advanced HD group. This may reflect HD related increases in myelin and/or iron in the cortex or a change in cytoarchitecture.

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