Abstract #3648

Intracortical T1-weighted/T2-weighted ratio signal changes in Huntington’s Disease

Christopher D Rowley¹, Sarah J Tabrizi², Blair R Leavitt³, Raymund A.C. Roos⁴, Alexandra Durr⁵, and Nicholas A Bock¹

¹Neuroscience, McMaster University, Hamilton, ON, Canada, ²University College London, London, United Kingdom, ³University of British Columbia, Vancouver, BC, Canada, ⁴Leiden University Medical Centre, Leiden, Netherlands, ⁵Institut du Cerveau et de la Moelle Epinière, Paris, France

Huntington’s disease (HD) is a genetic neurodegenerative disorder that is characterized by motor and cognitive dysfunction. Previous imaging studies have shown cortical thickness is reduced in HD, and here we investigated potential changes in cortical tissue composition in Huntington’s based on previously acquired T₁-weighted (T1W) and T₂-weighted (T2W) images. We analyzed T₁W/T₂W ratios formed using images collected in 321 subjects from the TRACK-HD dataset representing various stages of HD and healthy controls. Intracortical T₁W/T₂W signal analysis revealed significant changes in the most advanced HD group. This may reflect HD related increases in myelin and/or iron in the cortex or a change in cytoarchitecture.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.