The notion that the brain’s early-life retains hints to its end is an evolving avenue explored by basic and clinical researchers alike. Implementing neuroimaging, genetics and neuropsychological tests, our focus is to unravel the complex process of brain ageing through characterisation of normal brain development in a longitudinal ageing cohort. This approach has the power to unveil robust candidate determinants responsible for the vulnerability of the ageing brain to late-life pathology. We demonstrate statistically significant correlations between common genetic variants, white-matter integrity and cognitive ability and change, highlighting biological risk-factors as mediators of differential trajectories of ageing.
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