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Abstract #3653

Genetic influence on Brain Microstructure and Cognitive Function and Change in an Ageing Cohort

Kiyana Zarnani1,2, Jayachandra Raghava2, Naja Hansen3, Erik Mortensen1, Merete Osler1, Martin Lauritzen1, and Egill Rostrup4

1University of Copenhagen, Center For Healthy Ageing, Copenhagen, Denmark, 2Functional Imaging Unit, Dept. of Clinical Physiology, Nuclear Medicine and PET, University Hospital Rigshospitalet, Glostrup, Copenhagen, Denmark, 3Dept. of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark, 4Psychiatry, Glostrup Hospitalet, Glostrup Hospitalet, Copenhagen, Denmark

The notion that the brain’s early-life retains hints to its end is an evolving avenue explored by basic and clinical researchers alike. Implementing neuroimaging, genetics and neuropsychological tests, our focus is to unravel the complex process of brain ageing through characterisation of normal brain development in a longitudinal ageing cohort. This approach has the power to unveil robust candidate determinants responsible for the vulnerability of the ageing brain to late-life pathology. We demonstrate statistically significant correlations between common genetic variants, white-matter integrity and cognitive ability and change, highlighting biological risk-factors as mediators of differential trajectories of ageing.

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