Abstract #3654

Differences in Metabolite Concentration and fMRI Activation in Subjects with Low and High Genetic Risk During Face-Name Paired-Associates Encoding and Retrieval Task in Healthy Adults

H Zhang¹, PW Chiu^1,2, SWH Wong³, T Liu ⁴, GHY Wong⁴, Q Chan⁵, and HKF Mak^1,2,6

¹Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong, Hong Kong, ²State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong, Hong Kong, ³Department of Educational Psychology, Chinese University of Hong Kong, Hong Kong, Hong Kong, ⁴Department of Social Work and Administration, The University of Hong Kong, Hong Kong, Hong Kong, ⁵Philips Healthcare, Hong Kong, Hong Kong, ⁶Alzheimer’s Disease Research Network, The University of Hong Kong, Hong Kong, Hong Kong

APOE-ε4 is an important genetic risk factor of early onset of AD. To investigate the possible differences in metabolite concentration and fMRI activation in subjects with high risk of developing AD (APOE-ɛ4 positive) compared to those with low risk, we employed Face-Name Paired-Associates (FN-PA) Encoding and Retrieval Task and evaluated the absolute concentrations of Glx in bilateral hippocampi and whole brain BOLD signal changes. Significant metabolic and activation differences were observed in the left hippocampus of pre-symptomatic subjects with high genetic risk of developing AD compared to subjects with low risk.

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