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Abstract #3661

BIOmarkers of DEPression (BIODEP) study: Raised peripheral inflammation associated with changes in striatal microstructure

Charlotte L Clarke1, Manfred G Kitzbichler2, Gareth J Barker3, Marta M Correia2,4, Nick G Dowell1, Samuel A Hurley5, John Mclean6, Tobias Wood3, NIMA Consortium7, Mara Cercignani1, Ed T Bullmore2,8,9, and Neil A Harrison1

1Department of Neuroscience, Brighton and Sussex Medical School, Falmer, United Kingdom, 2Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom, 3Centre for Neuroimaging Sciences, Kings College London, London, United Kingdom, 4MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, United Kingdom, 5Oxford Centre for Functional MRI of the Brain, University of Oxford, Oxford, United Kingdom, 6NHS Greater Glasgow and Clyde, University of Glasgow, Glasgow, United Kingdom, 7-, -, United Kingdom, 8Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, United Kingdom, 9Immuno-Psychiatry, GlaxoSmithKline, Stevenage, United Kingdom

Inflammation is implicated in the aetiology of major depressive disorder (MDD) and is known to affect brain microstructure: e.g. the striatum as found with neurite orientation dispersion and density imaging (NODDI) and quantitative magnetization transfer (qMT) imaging. Further, individuals with high inflammation (C-reactive protein (CRP)>3mg) respond less well to antidepressants. The BIOmarkers of DEPression (BIODEP) multi-centre study is aiming to characterise the inflamed MDD phenotype. We report across-site data harmonization and interim results demonstrating a negative correlation between the water fraction content (NODDI) and CRP within the ventral striatum. Multi-modal imaging results (qMT, multi-component relaxometry) across the full cohort will be reported.

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