Abstract #3669

Rapid and robust high-resolution mapping of proton pool size ratio in spinal cord after injury in squirrel monkeys

Feng Wang^1,2, Tung-Lin Wu^1,3, Ke Li¹, Li Min Chen^1,2, and John C. Gore^1,2,3

¹Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States, ²Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, ³Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States

High-resolution quantitative magnetization transfer (qMT) MRI provides a noninvasive means to detect and characterize myelination before and after neural injury and during repair. This study aims to systematically evaluate the accuracy and precision of pool size ratio (PSR) measurements using either 5-, 2- or 1-parameter modeling for assessing injury-associated changes in spinal cords in squirrel monkeys in order to optimize a rapid, sensitive, and high-resolution PSR mapping protocol for applications in primates at high field. In addition, the sensitivity of PSR to demyelination in the dorsal pathway rostral and caudal to an injury site has been evaluated.

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