Abstract #3672

The effects of LIS1 deletion in the adult mouse brain and partial rescue by LiCl: A T2 mapping, magnetization transfer and diffusion MRI study

Hagit Dafni¹, Liraz Kaidar², Inbal E Biton¹, Aditya Kshirsagar², and Orly Reiner²

¹Department of Veterinary Resources, Weizmann Institute of Science, Rehovot, Israel, ²Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel

LIS1, a gene mutated in lissencephaly (“smooth brain”) have been investigated mainly in the developing brain. Initial studies demonstrated distinct ataxia and rapid lethality following Lis1 conditional deletion in adult mice. Therefore, our aim was to investigate the postnatal roles of LIS1 and the underlying mechanism. Conditional Lis1 knockout mice studied by MRI pre, and 5 days post, tamoxifen-induced Lis1 deletion, showed increase in T2 and ADC and decrease MTR and FA0, in the lateral ventricles and in brain regions related to motion and auditory functions. These alterations and changes in the Wnt pathway were partially rescued by LiCl treatment.

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