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Abstract #3673

Stability of silica coating of magnetic nanoparticles for cell tracking

Vít Herynek1, Lenka Kubíčková2, Ondřej Kaman3, Pavel Veverka3, and Milan Hájek1

1Institute for Clinical and Experimental Medicine, Prague, Czech Republic, 2Faculty of Mathematics and Physics, Charles University, Prague, Czech Republic, 3Institute of Physics of the Czech Academy of Sciences, Prague, Czech Republic

Magnetic nanoparticles are broadly used for cell tracking in vivo using magnetic resonance imaging. Silica coating, often used for magnetic nanoparticles, represents an inert and stable barrier between the nanoparticle core and cell environment. However, the coating may disintegrate at high temperatures and expose the core. We monitored this process using dynamic relaxometry and confirmed substantial extend of dissolution by transmission electron microscopy. The process probably reflected the equilibrium of solid silica and soluble silicic species in highly dilute suspensions at higher temperature.

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