Abstract #3689

Quantification of Oxygen Metabolism in Human Brain: Comparison of Direct 17O with Indirect 1H MR Method

Dmitry Kurzhunov¹, Jan Sedlacik², Robert Borowiak¹, Divya Sanam Bolar³, Johannes Fischer¹, Ali Caglar Özen^1,4, and Michael Bock¹

¹Department of Radiology, Medical Physics, Medical Center – University of Freiburg, Freiburg, Germany, ²Department of Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, ³Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ⁴German Consortium for Translational Cancer Research Freiburg Site, German Cancer Research Center (DKFZ), Heidelberg, Germany

In this study, quantification of the cerebral metabolic rate of oxygen consumption (CMRO₂) in human brain using direct dynamic ¹⁷O-MRI with inhalation of ¹⁷O gas was compared to indirect ¹H-MRI using QUantitative Imaging of eXtraction of Oxygen and TIssue Consumption (QUIXOTIC) method. The CMRO₂ results of both methods are in a good agreement with ¹⁵O-PET studies (¹⁷O-MRI: 0.83–1.09/1.13–1.48 µmol/g_tissue/min in WM/GM regions; ¹H-MRI: 0.40–1.45/0.74–1.73 µmol/g_tissue/min in WM/GM regions). QUIXOTIC offers smaller pixels which also results in a higher variation of CMRO₂ values, whereas MRI with the intracellular tracer ¹⁷O provides averaged values with less variation due to the lower spatial resolution.

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